This handbook identifies knowledge and practice gaps and proposes recommendations for innovative methods for academic collaboration with communities of practice. It serves as a valuable resource for enhancing the skills of emerging prevention scientists and clinicians. It also offers innovative strategies for experienced prevention experts to refine techniques and address persistent health disparities in sexual health outcomes. The book targets audiences across disciplines, including public health, sociology, psychology, nursing, medicine, anthropology, and population science and can be applied to marginalized communities globally. By bridging research, practice, and innovation, this book serves as a transformative resource for addressing sexual health disparities and empowering collaborative solutions to advance equity in the U.S. and around the globe.

This edited volume applies a Life Course framework to examine health and well-being among Black sexual minority men (SMM), a population that experiences distinct and intersecting vulnerabilities across social and cultural contexts. Although decades of U.S.-based HIV research have challenged myths about inherent risk among Black SMM, significant gaps remain in understanding the full range of their health experiences and trajectories. This book responds by situating HIV prevention within a broader continuum of infectious and chronic disease vulnerability, emphasizing the psychological, social, and historical factors that cumulatively produce vulnerability and resilience for this group. This volume integrates international evidence to addresses broader socioecological determinants and health issues across the lifespan and generate comparative insights that advance health research, policy, and practice for this population worldwide.