This handbook identifies knowledge and practice gaps and proposes recommendations for innovative methods for academic collaboration with communities of practice. It serves as a valuable resource for enhancing the skills of emerging prevention scientists and clinicians. It also offers innovative strategies for experienced prevention experts to refine techniques and address persistent health disparities in sexual health outcomes. The book targets audiences across disciplines, including public health, sociology, psychology, nursing, medicine, anthropology, and population science and can be applied to marginalized communities globally. By bridging research, practice, and innovation, this book serves as a transformative resource for addressing sexual health disparities and empowering collaborative solutions to advance equity in the U.S. and around the globe.